Publications

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Protective responses to sub-lytic complement in the retinal pigment epithelium.  Tan, LX, Toops, KA and Lakkaraju, A.  Proc Natl Acad Sci USA  113: 8789-94, 2016.

Apolipoprotein E isoforms in AMD. Toops, KA, Tan, LX and Lakkaraju, A. Adv Exp Med Biol. 854: 3-9, 2016.

Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Toops, KA, Tan, LX, Jiang, Z, Radu, RA and Lakkaraju, A. Mol Biol Cell. 26: 1-4, 2015.

Should I stay or should I go? Trafficking of sub-lytic membrane attack complex in the retinal pigment epithelium. Lakkaraju, A, Toops, KA, Xu, J. Adv Exp Med Biol. 801: 267-274, 2014.

A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers. Toops, KA, Tan LX and Lakkaraju, A. Exp Eye Res 124C: 74-85, 2014.

Let’s play a game of chutes and ladders: lysosome fusion with the epithelial plasma membrane. Toops, KA and Lakkaraju, A. Commun Integr Biol 6: e24474, 2013.

Mechanism of polarized lysosome exocytosis in epithelial cells.  Xu J, Toops KA, Diaz F, Carvajal-Gonzalez JM, Gravotta D, Mazzoni F, Schreiner R, Rodriguez-Boulan E, Lakkaraju A.  J Cell Sci. 125: 5937-43, 2012.

Endo-lysosome function in the retinal pigment epithelium in health and disease.  Lakkaraju A. Adv Exp Med Biol. 723:723-9, 2012.

It takes two to tango to the melanosome.  Lakkaraju A, Carvajal-Gonzalez JM, Rodriguez-Boulan E. J Cell Biol. 187(2):161-3, 2009.

In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate.  Thorne RG, Lakkaraju A, Rodriguez-Boulan E, Nicholson C.  Proc Natl Acad Sci U S A. 105(24):8416-21, 2008.

Itinerant exosomes: emerging roles in cell and tissue polarity.  Lakkaraju A, Rodriguez-Boulan E. Trends Cell Biol. 18(5):199-209, 2007.

Cell biology: caught in the traffic.  Lakkaraju A, Rodriguez-Boulan E. Nature. 448(7151):266-7, 2007.

The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells.  Lakkaraju A, Finnemann SC, Rodriguez-Boulan E.  Proc Natl Acad Sci U S A. 104(26):11026-31, 2007.

Evolving endosomes: how many varieties and why?  Perret E, Lakkaraju A, Deborde S, Schreiner R, Rodriguez-Boulan E. Curr Opin Cell Biol. 17(4):423-34, 2005.

Low-density lipoprotein receptor-related protein mediates the endocytosis of anionic liposomes in neurons. Lakkaraju A, Rahman YE, Dubinsky JM.  J Biol Chem. 277(17):15085-92, 2002.

Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes.  Lakkaraju A, Dubinsky JM, Low WC, Rahman YE.  J Biol Chem. 276(34):32000-7, 2001.

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